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Next-Gen Sequencing

Workflow solutions for nucleic acid analysis

AATI develops and manufactures capillary electrophoresis based solutions for nucleic acid analysis. The instruments employ parallel capillary electrophoresis, with UV absorbance or fluorescence detection, to streamline nucleic acid analysis and alleviate analytic bottlenecks. AATI’s nucleic acid analysis solutions are ideal for any application, from NGS library QC and CRISPR/Cas9 mutation detection to determining oligonucleotide purity and genomic DNA analysis.

APPLICATIONS

CELL-FREE DNA (cfDNA)

Analysis of cfDNA, such as mutation analysis and epigenetic alterations, is dependent upon next-generation sequencing (NGS) technologies. As such, cfDNA samples must undergo rigorous quality control analysis. The Fragment Analyzer™ Automated CE System, Fragment Analyzer INFINITY® Automated CE System, FEMTO Pulse™ Automated Pulsed-Field CE Instrument from Advanced Analytical Technologies, Inc. (AATI), with the associated reagent kits, provides a complete quality control solution for cfDNA samples.

PCR FRAGMENTS

AATI produces a variety of solutions for the complete and accurate analysis of PCR fragments across a broad range of amplicon lengths.

– Qualitative PCR Fragment Analysis
– Genetic Marker Detection

GENOMIC DNA

Advanced Analytical Technologies, Inc. manufactures several instruments and reagent kits well suited to the accurate quantification, qualification, and sizing of genomic DNA.

CELL-FREE DNA

CRISPR/Cas9

CRISPR gene editing has swept the life sciences by storm. Use the power of CE to streamline CRISPR

RNA ANALYSIS

In the endeavor to understand RNA biology, researchers have developed a multitude of relevant molecular biology techniques, ranging from reverse transcription PCR and agarose gel electrophoresis, to microarrays and next-generation sequencing. In the interest of streamlining and simplifying RNA analysis and QC workflows, Advanced Analytical Technologies, Inc. produces several solutions for RNA workflows.

– Total RNA
– Messenger RNA
– Small RNA
– FFPE RNA

NEXT-GEN  SEQUENCING

Was developed as a solution for the high-througput shortcomings of Sanger sequencing.

PCR-free libraries | RNA-Seq
ChIP-Seq | Long-Read Sequencing
Single-Cell Sequencing | Small RNA Libraries